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Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

Epigenetic deregulation of α‐synuclein plays a key role in Parkinson’s disease (PD). Analysis of the SNCA promoter using the ENCODE database revealed the presence of important histone post‐translational modifications (PTMs) including transcription‐promoting marks, H3K4me3 and H3K27ac, and repressive...

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Bibliografiset tiedot
Julkaisussa:EMBO Mol Med
Päätekijät: Guhathakurta, Subhrangshu, Kim, Jinil, Adams, Levi, Basu, Sambuddha, Song, Min Kyung, Adler, Evan, Je, Goun, Fiadeiro, Mariana Bernardo, Kim, Yoon‐Seong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863397/
https://ncbi.nlm.nih.gov/pubmed/33428332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012188
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