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Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation
Expanded polyglutamine (polyQ) sequences cause numerous neurodegenerative diseases which are accompanied by the formation of polyQ fibrils. The unique role of glutamines in the aggregation onset is undoubtedly accepted and a lot structural data of the fibrils have been acquired, however side-chain s...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7863018/ https://ncbi.nlm.nih.gov/pubmed/33552461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05299j |
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