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Insights into the Aggregation Mechanism of PolyQ Proteins with Different Glutamine Repeat Lengths

Polyglutamine (polyQ) diseases, including Huntington’s disease, result from the aggregation of an abnormally expanded polyQ repeat in the affected protein. The length of the polyQ repeat is essential for the disease’s onset; however, the molecular mechanism of polyQ aggregation is still poorly under...

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Библиографические подробности
Опубликовано в: :Biophys J
Главные авторы: Yushchenko, Tetyana, Deuerling, Elke, Hauser, Karin
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937114/
https://ncbi.nlm.nih.gov/pubmed/29694863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.02.037
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