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Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs

Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various anatomical sites during embryonic development. The in vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates some of these processes; however, it has proven difficult to generate functional hema...

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Pubblicato in:Blood
Autori principali: Fidanza, Antonella, Stumpf, Patrick S., Ramachandran, Prakash, Tamagno, Sara, Babtie, Ann, Lopez-Yrigoyen, Martha, Taylor, A. Helen, Easterbrook, Jennifer, Henderson, Beth E. P., Axton, Richard, Henderson, Neil C., Medvinsky, Alexander, Ottersbach, Katrin, Romanò, Nicola, Forrester, Lesley M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862875/
https://ncbi.nlm.nih.gov/pubmed/32614947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006229
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