TYK2 licenses non-canonical inflammasome activation during endotoxemia

The non-canonical inflammasome is an emerging crucial player in the development of inflammatory and neurodegenerative diseases. It is activated by direct sensing of cytosolic lipopolysaccharide (LPS) by caspase-11 (CASP11), which then induces pyroptosis, an inflammatory form of regulated cell death....

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Publicat a:Cell Death Differ
Autors principals: Poelzl, Andrea, Lassnig, Caroline, Tangermann, Simone, Hromadová, Dominika, Reichart, Ursula, Gawish, Riem, Mueller, Kristina, Moriggl, Richard, Linkermann, Andreas, Glösmann, Martin, Kenner, Lukas, Mueller, Mathias, Strobl, Birgit
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862449/
https://ncbi.nlm.nih.gov/pubmed/32929218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00621-x
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