Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the cysteine protease caspase 1 have long been sought as a therapeutic because mice lacking caspase 1 are resistant to LPS-induced endotoxic shock. According to current thinking, caspase 1-mediated shock requi...

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Bibliographic Details
Main Authors: Lamkanfi, Mohamed, Sarkar, Anasuya, Walle, Lieselotte Vande, Vitari, Alberto C., Amer, Amal O., Wewers, Mark D., Tracey, Kevin J., Kanneganti, Thirumala-Devi, Dixit, Vishva M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428148/
https://ncbi.nlm.nih.gov/pubmed/20802146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000803
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