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Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the cysteine protease caspase 1 have long been sought as a therapeutic because mice lacking caspase 1 are resistant to LPS-induced endotoxic shock. According to current thinking, caspase 1-mediated shock requi...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428148/ https://ncbi.nlm.nih.gov/pubmed/20802146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000803 |
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