NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity

Tyrosine kinase 2 (TYK2) is a widely expressed receptor-associated kinase that is involved in signaling by a variety of cytokines with important immune regulatory activities. Absence of TYK2 in mice results in impaired NK cell maturation and antitumor activity, although underlying mechanisms are lar...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Simonović, Natalija, Witalisz-Siepracka, Agnieszka, Meissl, Katrin, Lassnig, Caroline, Reichart, Ursula, Kolbe, Thomas, Farlik, Matthias, Bock, Christoph, Sexl, Veronika, Müller, Mathias, Strobl, Birgit
Format: Artigo
Jezik:Inglês
Izdano: AAI 2019
Teme:
Immune Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398083/
https://ncbi.nlm.nih.gov/pubmed/30718299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701649
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