In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in inflammation, carcinogenesis and defense against infection. The cytotoxic activity of natural killer (NK) cells in TYK2-deficient (Tyk2(−/−)) mice is severely reduced, although the underlying mechanisms are largely unknow...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Prchal-Murphy, Michaela, Witalisz-Siepracka, Agnieszka, Bednarik, Karoline T, Putz, Eva Maria, Gotthardt, Dagmar, Meissl, Katrin, Sexl, Veronika, Müller, Mathias, Strobl, Birgit
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589058/
https://ncbi.nlm.nih.gov/pubmed/26451322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1047579
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