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In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity
Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in inflammation, carcinogenesis and defense against infection. The cytotoxic activity of natural killer (NK) cells in TYK2-deficient (Tyk2(−/−)) mice is severely reduced, although the underlying mechanisms are largely unknow...
שמור ב:
| הוצא לאור ב: | Oncoimmunology |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Taylor & Francis
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589058/ https://ncbi.nlm.nih.gov/pubmed/26451322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1047579 |
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