Separate signaling events control TCR downregulation and T cell activation in primary human T cells

INTRODUCTION: T‐cell antigen receptor (TCR) interaction with cognate peptide:MHC complexes trigger clustering of TCR:CD3 complexes and signal transduction. Triggered TCR:CD3 complexes are rapidly internalized and degraded in a process called ligand‐induced TCR downregulation. Classic studies in immo...

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Udgivet i:Immun Inflamm Dis
Main Authors: van der Donk, Lieve E. H., Ates, Louis S., van der Spek, Jet, Tukker, Laura M., Geijtenbeek, Teunis B. H., van Heijst, Jeroen W. J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7860602/
https://ncbi.nlm.nih.gov/pubmed/33350598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iid3.383
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