Control of T cell antigen reactivity via programmed TCR downregulation

The T cell receptor (TCR) is unique in that its affinity for ligand is unknown prior to encounter and can vary by orders of magnitude. How the immune system regulates individual T cells that display highly different reactivity to antigen remains unclear. Here we identified that activated CD4(+) T ce...

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Bibliographic Details
Published in:Nat Immunol
Main Authors: Gallegos, Alena M, Xiong, Huizhong, Leiner, Ingrid M, Sušac, Bože, Glickman, Michael S, Pamer, Eric G, van Heijst, Jeroen W J
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803589/
https://ncbi.nlm.nih.gov/pubmed/26901151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3386
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