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Influence of the pK(a) Value of Cinnamic Acid and P-Hydroxycinnamic Acid on the Solubility of a Lurasidone Hydrochloride-Based Coamorphous System
[Image: see text] Coamorphization of a poorly water-soluble active pharmaceutical ingredient (API) has been proven to be effective in improving its solubility. Generally, API can form multiple coamorphous systems with different coformers. However, it remains unclear how the pK(a) value of different...
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| Publicado no: | ACS Omega |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2021
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7860058/ https://ncbi.nlm.nih.gov/pubmed/33553927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c05510 |
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