RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells

Advanced glycation end-products (AGEs) are formed by the non-enzymatic reaction of sugars and proteins. Among the AGEs, glyceraldehyde-derived toxic AGEs (TAGE) are associated with various diseases, including diabetic complications such as diabetic retinopathy (DR). The risk of developing DR is stro...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Takino, Jun-ichi, Sato, Takuma, Kanetaka, Takumi, Okihara, Kasumi, Nagamine, Kentaro, Takeuchi, Masayoshi, Hori, Takamitsu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7859393/
https://ncbi.nlm.nih.gov/pubmed/33536515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82619-0
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