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The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomously

VAMP/synaptobrevin-associated protein B (VAP-B) is a type II ER membrane protein, but its N-terminal MSP domain (MSPd) can be cleaved and secreted. Mutations preventing the cleavage and secretion of MSPd have been implicated in cases of human neurodegenerative diseases. The site of VAP cleavage and...

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Detalhes bibliográficos
Publicado no:Dev Biol
Main Authors: Zein-Sabatto, Hala, Cole, Tim, Hoang, Hieu D., Tiwary, Ekta, Chang, Chenbei, Miller, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856274/
https://ncbi.nlm.nih.gov/pubmed/33160939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2020.10.015
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