Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma

Prognosis for patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains poor. Development of more effective and less toxic targeted therapies is necessary for HNSCC patients. Checkpoint kinase 1 (CHK1) plays a vital role in cell cycle regulation and is a promisi...

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Publicado no:Mol Carcinog
Main Authors: Chaudhary, Ritu, Slebos, Robbert J. C., Song, Feifei, McCleary-Sharpe, Keegan P., Masannat, Jude, Tan, Aik Choon, Wang, Xuefeng, Amaladas, Nelusha, Wu, Wenjuan, Hall, Gerald E., Conejo-Garcia, Jose R., Hernandez-Prera, Juan C., Chung, Christine H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856233/
https://ncbi.nlm.nih.gov/pubmed/33378592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.23275
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