Competition for active TGFβ cytokine allows for selective retention of antigen-specific tissue resident memory T cells in the epidermal niche

Following antigen-driven expansion in lymph node, transforming growth factor-β (TGFβ) is required for differentiation of skin-recruited CD8(+) T cell effectors into epidermal resident memory T cells (Trm) and their epidermal persistence. We found that the source of TGFβ supporting Trm cells was auto...

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Publicado no:Immunity
Main Authors: Hirai, Toshiro, Yang, Yi, Zenke, Yukari, Li, Haiyue, Chaudhri, Virendra K., De La Cruz Diaz, Jacinto S., Zhou, Paul Yifan, Nguyen, Breanna Anh-Thu, Bartholin, Laurent, Workman, Creg J., Griggs, David W., Vignali, Dario A. A., Singh, Harinder, Masopust, David, Kaplan, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856016/
https://ncbi.nlm.nih.gov/pubmed/33212014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.10.022
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