General Light-Mediated, Highly Diastereoselective Piperidine Epimerization: From Most Accessible to Most Stable Stereoisomer

We report a combined photocatalytic and hydrogen atom transfer (HAT) approach for the light-mediated epimerization of readily accessible piperidines to provide the more stable diastereomer with high selectivity. The generality of the transformation was explored for a large variety of di- to tetrasub...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Shen, Zican, Walker, Morgan M., Chen, Shuming, Parada, Giovanny A., Chu, Duc M., Dongbang, Sun, Mayer, James M., Houk, K. N., Ellman, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855822/
https://ncbi.nlm.nih.gov/pubmed/33373212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c11911
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