Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

Linker histone H1 proteins bind to nucleosomes and facilitate chromatin compaction(1), although their biological functions are poorly understood. Histone H1 (HIST1H1B-E) mutations are highly recurrent in B-cell lymphomas, but their cancer relevance and mechanism are unknown. Here we show that lympho...

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Publicado no:Nature
Main Authors: Yusufova, Nevin, Kloetgen, Andreas, Teater, Matt, Osunsade, Adewola, Camarillo, Jeannie M., Chin, Christopher R., Doane, Ashley S., Venters, Bryan J., Portillo-Ledesma, Stephanie, Conway, Joseph, Phillip, Jude M., Elemento, Olivier, Scott, David W., Béguelin, Wendy, Licht, Jonathan D., Kelleher, Neil L., Staudt, Louis M, Skoultchi, Arthur I., Keogh, Michael-Christopher, Apostolou, Eftychia, Mason, Christopher E., Imielinski, Marcin, Schlick, Tamar, David, Yael, Tsirigos, Aristotelis, Allis, C. David, Soshnev, Alexey A., Cesarman, Ethel, Melnick, Ari M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855728/
https://ncbi.nlm.nih.gov/pubmed/33299181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-3017-y
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