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Granzyme B inhibition by tofacitinib blocks pathology induced by CD8 T cells in cutaneous leishmaniasis

In cutaneous leishmaniasis (CL) the immune response is not only protective, but also mediates immunopathology. We previously found that cytolytic CD8 T cells promote inflammatory responses that are difficult to treat with conventional therapies that target the parasite. Therefore, we hypothesized th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Invest Dermatol
Prif Awduron: Novais, Fernanda O., Nguyen, Ba T., Scott, Phillip
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855313/
https://ncbi.nlm.nih.gov/pubmed/32738245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.07.011
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