Granzyme B Produced by Natural Killer Cells Enhances Inflammatory Response and Contributes to the Immunopathology of Cutaneous Leishmaniasis

BACKGROUND: Skin lesions from patients infected with Leishmania braziliensis has been associated with inflammation induced by cytotoxic CD8(+) T cells. In addition, CD8(+) T cell-mediated cytotoxicity has not been linked to parasite killing. Meanwhile, the cytotoxic role played by natural killer (NK...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Campos, Taís M, Novais, Fernanda O, Saldanha, Maíra, Costa, Rúbia, Lordelo, Morgana, Celestino, Daniela, Sampaio, Camilla, Tavares, Natália, Arruda, Sérgio, Machado, Paulo, Brodskyn, Cláudia, Scott, Phillip, Carvalho, Edgar M, Carvalho, Lucas P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050991/
https://ncbi.nlm.nih.gov/pubmed/31748808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz538
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