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Granzyme B inhibition by tofacitinib blocks pathology induced by CD8 T cells in cutaneous leishmaniasis
In cutaneous leishmaniasis (CL) the immune response is not only protective, but also mediates immunopathology. We previously found that cytolytic CD8 T cells promote inflammatory responses that are difficult to treat with conventional therapies that target the parasite. Therefore, we hypothesized th...
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| Publicado no: | J Invest Dermatol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855313/ https://ncbi.nlm.nih.gov/pubmed/32738245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.07.011 |
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