Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification

SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates (dNTPs)—implicates enzymatic dNTP depletion in innate antiviral immunity. Here we show that the allosteric binding sites o...

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Pubblicato in:Nat Commun
Autori principali: Yu, Corey H., Bhattacharya, Akash, Persaud, Mirjana, Taylor, Alexander B., Wang, Zhonghua, Bulnes-Ramos, Angel, Xu, Joella, Selyutina, Anastasia, Martinez-Lopez, Alicia, Cano, Kristin, Demeler, Borries, Kim, Baek, Hardies, Stephen C., Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854603/
https://ncbi.nlm.nih.gov/pubmed/33531504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21023-8
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