Regulation of CEACAM5 and therapeutic efficacy of an anti-CEACAM5-SN38 antibody-drug conjugate in neuroendocrine prostate cancer

PURPOSE: Neuroendocrine prostate cancer (NEPC) is an aggressive form of castration-resistant prostate cancer (CRPC) for which effective therapies are lacking. We previously identified carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) as a promising NEPC cell surface antigen. Here w...

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Pubblicato in:Clin Cancer Res
Autori principali: DeLucia, Diana C., Cardillo, Thomas M., Ang, Lisa, Labrecque, Mark P., Zhang, Ailin, Hopkins, James E., De Sarkar, Navonil, Coleman, Ilsa, da Costa, Rui M. Gil, Corey, Eva, True, Lawrence D., Haffner, Michael C., Schweizer, Michael T., Morrissey, Colm, Nelson, Peter S., Lee, John K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854497/
https://ncbi.nlm.nih.gov/pubmed/33199493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3396
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