CEACAM5-Targeted Therapy of Human Colonic and Pancreatic Cancer Xenografts with Potent Labetuzumab-SN-38 Immunoconjugates

PURPOSE: To improve the efficacy and reduce the gastrointestinal toxicity of the cancer prodrug, CPT-11, we have developed immunoconjugates of its active form, SN-38, and an anti-CEACAM5 antibody for targeted chemotherapy. EXPERIMENTAL DESIGN: SN-38 conjugates of the anti-CEACAM5 mAb, labetuzumab (h...

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Bibliografiske detaljer
Main Authors: Govindan, Serengulam V., Cardillo, Thomas M., Moon, Sung-Ju, Hansen, Hans J., Goldenberg, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769088/
https://ncbi.nlm.nih.gov/pubmed/19789330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0586
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