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Regulation of CEACAM5 and therapeutic efficacy of an anti-CEACAM5-SN38 antibody-drug conjugate in neuroendocrine prostate cancer

PURPOSE: Neuroendocrine prostate cancer (NEPC) is an aggressive form of castration-resistant prostate cancer (CRPC) for which effective therapies are lacking. We previously identified carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) as a promising NEPC cell surface antigen. Here w...

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Библиографические подробности
Опубликовано в: :Clin Cancer Res
Главные авторы: DeLucia, Diana C., Cardillo, Thomas M., Ang, Lisa, Labrecque, Mark P., Zhang, Ailin, Hopkins, James E., De Sarkar, Navonil, Coleman, Ilsa, da Costa, Rui M. Gil, Corey, Eva, True, Lawrence D., Haffner, Michael C., Schweizer, Michael T., Morrissey, Colm, Nelson, Peter S., Lee, John K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854497/
https://ncbi.nlm.nih.gov/pubmed/33199493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3396
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