Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo

We recently reported the antisense properties of a DNA/RNA heteroduplex oligonucleotide consisting of a phosphorothioate DNA-gapmer antisense oligonucleotide (ASO) strand and its complementary phosphodiester RNA/phosphorothioate 2′-O-methyl RNA strand. When α-tocopherol was conjugated with the compl...

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Bibliografske podrobnosti
izdano v:Mol Ther
Main Authors: Asami, Yutaro, Nagata, Tetsuya, Yoshioka, Kotaro, Kunieda, Taiki, Yoshida-Tanaka, Kie, Bennett, C. Frank, Seth, Punit P., Yokota, Takanori
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2021
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854292/
https://ncbi.nlm.nih.gov/pubmed/33290725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.10.017
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