Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes

Immunotherapies designed to treat neurodegenerative tauopathies that primarily engage extracellular tau may have limited efficacy as tau is primarily intracellular. We generated tau-targeting single-chain variable fragments (scFvs) and intrabodies (iBs) from the phosphorylated tau-specific antibodie...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther
Hoofdauteurs: Goodwin, Marshall S., Sinyavskaya, Olga, Burg, Franklin, O’Neal, Veronica, Ceballos-Diaz, Carolina, Cruz, Pedro E., Lewis, Jada, Giasson, Benoit I., Davies, Peter, Golde, Todd E., Levites, Yona
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2021
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854277/
https://ncbi.nlm.nih.gov/pubmed/33128896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.10.007
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