Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes

Immunotherapies designed to treat neurodegenerative tauopathies that primarily engage extracellular tau may have limited efficacy as tau is primarily intracellular. We generated tau-targeting single-chain variable fragments (scFvs) and intrabodies (iBs) from the phosphorylated tau-specific antibodie...

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Publicat a:Mol Ther
Autors principals: Goodwin, Marshall S., Sinyavskaya, Olga, Burg, Franklin, O’Neal, Veronica, Ceballos-Diaz, Carolina, Cruz, Pedro E., Lewis, Jada, Giasson, Benoit I., Davies, Peter, Golde, Todd E., Levites, Yona
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2021
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854277/
https://ncbi.nlm.nih.gov/pubmed/33128896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.10.007
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