Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer. However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Li, Zhongwei, Wang, Diandian, Lu, Jun, Huang, Baiqu, Wang, Yibo, Dong, Meichen, Fan, Dongmei, Li, Hongyuan, Gao, Yanyan, Hou, Pingfu, Li, Minle, Liu, Hui, Pan, Zhen-Qiang, Zheng, Junnian, Bai, Jin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853151/
https://ncbi.nlm.nih.gov/pubmed/32895488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00615-9
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