Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer. However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylat...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Li, Zhongwei, Wang, Diandian, Lu, Jun, Huang, Baiqu, Wang, Yibo, Dong, Meichen, Fan, Dongmei, Li, Hongyuan, Gao, Yanyan, Hou, Pingfu, Li, Minle, Liu, Hui, Pan, Zhen-Qiang, Zheng, Junnian, Bai, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853151/
https://ncbi.nlm.nih.gov/pubmed/32895488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00615-9
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