Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer. However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylat...

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Publicat a:Cell Death Differ
Autors principals: Li, Zhongwei, Wang, Diandian, Lu, Jun, Huang, Baiqu, Wang, Yibo, Dong, Meichen, Fan, Dongmei, Li, Hongyuan, Gao, Yanyan, Hou, Pingfu, Li, Minle, Liu, Hui, Pan, Zhen-Qiang, Zheng, Junnian, Bai, Jin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853151/
https://ncbi.nlm.nih.gov/pubmed/32895488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00615-9
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