RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

Tauopathies are a group of neurodegenerative diseases characterized by hyperphosphorylation of the microtubule-binding protein, tau, and typically feature axon impairment and synaptic dysfunction. Cyclin-dependent kinase5 (Cdk5) is a major tau kinase and its activity requires p35 or p25 regulatory s...

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Udgivet i:Cell Death Differ
Main Authors: Zhao, Dongdong, Zhou, Yunqiang, Huo, Yuanhui, Meng, Jian, Xiao, Xiaoxia, Han, Linkun, Zhang, Xian, Luo, Hong, Can, Dan, Sun, Hao, Huang, Timothy Y., Wang, Xin, Zhang, Jie, Liu, Fa-rong, Xu, Huaxi, Zhang, Yun-wu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853145/
https://ncbi.nlm.nih.gov/pubmed/32908202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00620-y
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