MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3(+) regulatory T cells

FOXP3(+) regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related diseases, cancer and obesity, there is increasing interest in targeting the Treg cell compartment therapeutically. New pharmacological inhibitors that specifically targe...

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Udgivet i:Cell Death Differ
Main Authors: Teh, Charis E., Robbins, Alissa K., Henstridge, Darren C., Dewson, Grant, Diepstraten, Sarah T., Kelly, Gemma, Febbraio, Mark A., Gabriel, Sarah S., O’Reilly, Lorraine A., Strasser, Andreas, Gray, Daniel H. D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853142/
https://ncbi.nlm.nih.gov/pubmed/32612106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0585-1
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