Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis and induces neuropathological changes, such as impaired neuronal integrity, neurodegeneration, and cognitive impairment. Regulation of mitochondrial calcium influx from the endoplasmic reticulum (ER) is consid...

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Publicado en:Cell Death Differ
Autores principales: Lee, Hyun Jik, Jung, Young Hyun, Choi, Gee Euhn, Kim, Jun Sung, Chae, Chang Woo, Lim, Jae Ryong, Kim, Seo Yihl, Yoon, Jee Hyeon, Cho, Ji Hyeon, Lee, Sei-Jung, Han, Ho Jae
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852667/
https://ncbi.nlm.nih.gov/pubmed/32704090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0593-1
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