Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1

The gut–brain axis is currently being studied as a therapeutic strategy for neurological diseases, especially Alzheimer’s disease (AD). Obesity results in the gut microbiota dysbiosis, which includes butyrate-producing bacteria are reduced. Although sodium butyrate (NaB) has emerged as the potential...

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Udgivet i:Cell Death Dis
Main Authors: Kim, Seo Yihl, Chae, Chang Woo, Lee, Hyun Jik, Jung, Young Hyun, Choi, Gee Euhn, Kim, Jun Sung, Lim, Jae Ryong, Lee, Joo Eun, Cho, Ji Hyeon, Park, Hansoo, Park, Changho, Han, Ho Jae
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303181/
https://ncbi.nlm.nih.gov/pubmed/32555166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2663-1
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