Extrahepatic metabolism of ibrutinib

Ibrutinib is a first-in-class Bruton’s kinase inhibitor used in the treatment of multiple lymphomas. In addition to CYP3A4-mediated metabolism, glutathione conjugation can be observed. Subsequently, metabolism of the conjugates and finally their excretion in feces and urine occurs. These metabolites...

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Detalhes bibliográficos
Publicado no:Invest New Drugs
Main Authors: Rood, Johannes J. M., Jamalpoor, Amer, van Hoppe, Stephanie, van Haren, Matthijs J., Wasmann, Roeland E., Janssen, Manoe J., Schinkel, Alfred H., Masereeuw, Rosalinde, Beijnen, Jos H., Sparidans, Rolf W.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Preclinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851014/
https://ncbi.nlm.nih.gov/pubmed/32623551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-020-00970-x
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