The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32

BACKGROUND: Metformin has been associated with lower breast cancer (BC) risk and improved outcomes in observational studies. Multiple biologic mechanisms have been proposed, including a recent report of altered sex hormones. We evaluated the effect of metformin on sex hormones in MA.32, a phase III...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Pimentel, Isabel, Chen, Bingshu E, Lohmann, Ana Elisa, Ennis, Marguerite, Ligibel, Jennifer, Shepherd, Lois, Hershman, Dawn L, Whelan, Timothy, Stambolic, Vuk, Mayer, Ingrid, Hobday, Timothy, Lemieux, Julie, Thompson, Alastair, Rastogi, Priya, Gelmon, Karen, Rea, Daniel, Rabaglio, Manuela, Ellard, Susan, Mates, Mihaela, Bedard, Philippe, Pitre, Lacey, Vandenberg, Theodore, Dowling, Ryan J O, Parulekar, Wendy, Goodwin, Pamela J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7850529/
https://ncbi.nlm.nih.gov/pubmed/33527137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djaa082
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