Effect of metformin versus placebo on metabolic factors in the MA.32 randomized breast cancer trial

Metformin may exert anticancer effects through indirect (mediated by metabolic changes) or direct mechanisms. The goal was to examine metformin impact on metabolic factors in non-diabetic subjects and determine whether this impact varies by baseline BMI, insulin, and rs11212617 SNP in CCTG MA.32, a...

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Pubblicato in:NPJ Breast Cancer
Autori principali: Goodwin, Pamela J., Dowling, Ryan J. O., Ennis, Marguerite, Chen, Bingshu E., Parulekar, Wendy R., Shepherd, Lois E., Burnell, Margot J., Vander Meer, Rachel, Molckovsky, Andrea, Gurjal, Anagha, Gelmon, Karen A., Ligibel, Jennifer A., Hershman, Dawn L., Mayer, Ingrid A., Whelan, Timothy J., Hobday, Timothy J., Rastogi, Priya, Rabaglio-Poretti, Manuela, Lemieux, Julie, Thompson, Alastair M., Rea, Daniel W., Stambolic, Vuk
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187713/
https://ncbi.nlm.nih.gov/pubmed/34103538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-021-00275-z
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