Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

The hematopoietic system is highly sensitive to perturbations in the translational machinery, of which an emerging level of regulation lies in the epitranscriptomic modification of transfer RNAs (tRNAs). Here, we interrogate the role of tRNA anticodon modifications in hematopoiesis by using mouse mo...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Rosu, Adeline, El Hachem, Najla, Rapino, Francesca, Rouault-Pierre, Kevin, Jorssen, Joseph, Somja, Joan, Ramery, Eve, Thiry, Marc, Nguyen, Laurent, Jacquemyn, Maarten, Daelemans, Dirk, Adams, Christopher M., Bonnet, Dominique, Chariot, Alain, Close, Pierre, Bureau, Fabrice, Desmet, Christophe J.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849823/
https://ncbi.nlm.nih.gov/pubmed/33507234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200662
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