Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs (tRNAs) at the wobble uridine 34 (U34) base are highly conserved and contribute to translation fidelity. Here, we show that...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Delaunay, Sylvain, Rapino, Francesca, Tharun, Lars, Zhou, Zhaoli, Heukamp, Lukas, Termathe, Martin, Shostak, Kateryna, Klevernic, Iva, Florin, Alexandra, Desmecht, Hadrien, Desmet, Christophe J., Nguyen, Laurent, Leidel, Sebastian A., Willis, Anne E., Büttner, Reinhard, Chariot, Alain, Close, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068235/
https://ncbi.nlm.nih.gov/pubmed/27811057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160397
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