Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs (tRNAs) at the wobble uridine 34 (U34) base are highly conserved and contribute to translation fidelity. Here, we show that...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Delaunay, Sylvain, Rapino, Francesca, Tharun, Lars, Zhou, Zhaoli, Heukamp, Lukas, Termathe, Martin, Shostak, Kateryna, Klevernic, Iva, Florin, Alexandra, Desmecht, Hadrien, Desmet, Christophe J., Nguyen, Laurent, Leidel, Sebastian A., Willis, Anne E., Büttner, Reinhard, Chariot, Alain, Close, Pierre
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068235/
https://ncbi.nlm.nih.gov/pubmed/27811057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160397
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