Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

Tumor initiation in the intestine can rapidly occur from Lgr5(+) crypt columnar stem cells. Dclk1 is a marker of differentiated Tuft cells and, when coexpressed with Lgr5, also marks intestinal cancer stem cells. Here, we show that Elp3, the catalytic subunit of the Elongator complex, is required fo...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Ladang, Aurélie, Rapino, Francesca, Heukamp, Lukas C., Tharun, Lars, Shostak, Kateryna, Hermand, Damien, Delaunay, Sylvain, Klevernic, Iva, Jiang, Zheshen, Jacques, Nicolas, Jamart, Diane, Migeot, Valérie, Florin, Alexandra, Göktuna, Serkan, Malgrange, Brigitte, Sansom, Owen J., Nguyen, Laurent, Büttner, Reinhard, Close, Pierre, Chariot, Alain
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647259/
https://ncbi.nlm.nih.gov/pubmed/26527802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142288
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