Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

Tumor initiation in the intestine can rapidly occur from Lgr5(+) crypt columnar stem cells. Dclk1 is a marker of differentiated Tuft cells and, when coexpressed with Lgr5, also marks intestinal cancer stem cells. Here, we show that Elp3, the catalytic subunit of the Elongator complex, is required fo...

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Pubblicato in:J Exp Med
Autori principali: Ladang, Aurélie, Rapino, Francesca, Heukamp, Lukas C., Tharun, Lars, Shostak, Kateryna, Hermand, Damien, Delaunay, Sylvain, Klevernic, Iva, Jiang, Zheshen, Jacques, Nicolas, Jamart, Diane, Migeot, Valérie, Florin, Alexandra, Göktuna, Serkan, Malgrange, Brigitte, Sansom, Owen J., Nguyen, Laurent, Büttner, Reinhard, Close, Pierre, Chariot, Alain
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2015
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647259/
https://ncbi.nlm.nih.gov/pubmed/26527802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142288
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