Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate

Regulation of mRNA translation elongation impacts nascent protein synthesis and integrity and plays a critical role in disease establishment. Here, we investigate features linking regulation of codon-dependent translation elongation to protein expression and homeostasis. Using knockdown models of en...

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Publicado no:Nat Commun
Main Authors: Rapino, Francesca, Zhou, Zhaoli, Roncero Sanchez, Ana Maria, Joiret, Marc, Seca, Christian, El Hachem, Najla, Valenti, Gianluca, Latini, Sara, Shostak, Kateryna, Geris, Liesbet, Li, Ping, Huang, Gang, Mazzucchelli, Gabriel, Baiwir, Dominique, Desmet, Christophe J., Chariot, Alain, Georges, Michel, Close, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050329/
https://ncbi.nlm.nih.gov/pubmed/33859181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22254-5
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