Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate

Regulation of mRNA translation elongation impacts nascent protein synthesis and integrity and plays a critical role in disease establishment. Here, we investigate features linking regulation of codon-dependent translation elongation to protein expression and homeostasis. Using knockdown models of en...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Rapino, Francesca, Zhou, Zhaoli, Roncero Sanchez, Ana Maria, Joiret, Marc, Seca, Christian, El Hachem, Najla, Valenti, Gianluca, Latini, Sara, Shostak, Kateryna, Geris, Liesbet, Li, Ping, Huang, Gang, Mazzucchelli, Gabriel, Baiwir, Dominique, Desmet, Christophe J., Chariot, Alain, Georges, Michel, Close, Pierre
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050329/
https://ncbi.nlm.nih.gov/pubmed/33859181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22254-5
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