Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence

Deregulated expression of the MYC oncogene is a frequent event during tumorigenesis and generally correlates with aggressive disease and poor prognosis. While MYC is a potent inducer of apoptosis, it often suppresses cellular senescence, which together with apoptosis is an important barrier against...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Bazzar, Wesam, Bocci, Matteo, Hejll, Eduar, Högqvist Tabor, Vedrana, Hydbring, Per, Grandien, Alf, Alzrigat, Mohammad, Larsson, Lars-Gunnar
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849765/
https://ncbi.nlm.nih.gov/pubmed/33356836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1855740
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