An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia

Reactive oxygen species (ROS) produced by NADPH1 oxidase 1 (NOX1) are thought to drive spermatogonial stem cell (SSC) self-renewal through feed-forward production of ROS by the ROS-BCL6B-NOX1 pathway. Here we report the critical role of oxygen on ROS-induced self-renewal. Cultured SSCs proliferated...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Morimoto, Hiroko, Yamamoto, Takuya, Miyazaki, Takehiro, Ogonuki, Narumi, Ogura, Atsuo, Tanaka, Takashi, Kanatsu-Shinohara, Mito, Yabe-Nishimura, Chihiro, Zhang, Hongliang, Pommier, Yves, Trumpp, Andreas, Shinohara, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849365/
https://ncbi.nlm.nih.gov/pubmed/33446567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.339903.120
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