Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal

Spermatogonial stem cells (SSCs) are required for spermatogenesis. Earlier studies showed that glial cell line-derived neurotrophic factor (GDNF) was indispensable for SSC self-renewal by binding to the GFRA1/RET receptor. Mice with mutations in these molecules showed impaired spermatogenesis, which...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Takashima, Seiji, Kanatsu-Shinohara, Mito, Tanaka, Takashi, Morimoto, Hiroko, Inoue, Kimiko, Ogonuki, Narumi, Jijiwa, Mayumi, Takahashi, Masahide, Ogura, Atsuo, Shinohara, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375941/
https://ncbi.nlm.nih.gov/pubmed/25684228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.01.010
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