Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived from the gut microbiota, which has the potential to manage PD. Osteocalcin (OCN),...

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Detalhes bibliográficos
Publicado no:Microbiome
Main Authors: Hou, Yan-fang, Shan, Chang, Zhuang, Si-yue, Zhuang, Qian-qian, Ghosh, Arijit, Zhu, Ke-cheng, Kong, Xiao-ke, Wang, Shu-min, Gong, Yan-ling, Yang, Yu-ying, Tao, Bei, Sun, Li-hao, Zhao, Hong-Yan, Guo, Xing-zhi, Wang, Wei-qing, Ning, Guang, Gu, Yan-yun, Li, Sheng-tian, Liu, Jian-min
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849090/
https://ncbi.nlm.nih.gov/pubmed/33517890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-020-00988-6
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