Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived from the gut microbiota, which has the potential to manage PD. Osteocalcin (OCN),...

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Vydáno v:Microbiome
Hlavní autoři: Hou, Yan-fang, Shan, Chang, Zhuang, Si-yue, Zhuang, Qian-qian, Ghosh, Arijit, Zhu, Ke-cheng, Kong, Xiao-ke, Wang, Shu-min, Gong, Yan-ling, Yang, Yu-ying, Tao, Bei, Sun, Li-hao, Zhao, Hong-Yan, Guo, Xing-zhi, Wang, Wei-qing, Ning, Guang, Gu, Yan-yun, Li, Sheng-tian, Liu, Jian-min
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849090/
https://ncbi.nlm.nih.gov/pubmed/33517890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-020-00988-6
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