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The Hepatocyte Clock and Feeding Control Chronophysiology of Multiple Liver Cell Types

Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for rhythmicity, and their effects on physiology, are not well understood. Here we show that deletion of core clock components REV-ERBα and β in adult mouse hepatocytes disrupted diurnal rhythms of a subset of...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Guan, Dongyin, Xiong, Ying, Trinh, Trang Minh, Xiao, Yang, Hu, Wenxiang, Jiang, Chunjie, Dierickx, Pieterjan, Jang, Cholsoon, Rabinowitz, Joshua D., Lazar, Mitchell A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849028/
https://ncbi.nlm.nih.gov/pubmed/32732282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aba8984
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