Patient adipose stem cell-derived adipocytes reveal genetic variation that predicts anti-diabetic drug response

Thiazolidinedione drugs (TZDs) target the transcriptional activity of PPARγ to reverse insulin resistance in type 2 diabetes, but side effects limit their clinical use. Here, using human adipose stem cell-derived adipocytes, we demonstrate that single-nucleotide polymorphisms (SNPs) were enriched at...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Stem Cell
Prif Awduron: Hu, Wenxiang, Jiang, Chunjie, Guan, Dongyin, Dierickx, Pieterjan, Zhang, Rong, Moscati, Arden, Nadkarni, Girish N., Steger, David J., Loos, Ruth J.F., Hu, Cheng, Jia, Weiping, Soccio, Raymond E., Lazar, Mitchell A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368460/
https://ncbi.nlm.nih.gov/pubmed/30639037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.11.018
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