Pseudomonas aeruginosa Polynucleotide Phosphorylase Controls Tolerance to Aminoglycoside Antibiotics by Regulating the MexXY Multidrug Efflux Pump

Pseudomonas aeruginosa is an opportunistic pathogen that shows high intrinsic resistance to a variety of antibiotics. The MexX-MexY-OprM efflux pump plays an important role in bacterial resistance to aminoglycoside antibiotics. Polynucleotide phosphorylase (PNPase) is a highly conserved exonuclease...

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Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Fan, Zheng, Pan, Xiaolei, Wang, Dan, Chen, Ronghao, Fu, Tongtong, Yang, Baopeng, Jin, Yongxin, Bai, Fang, Cheng, Zhihui, Wu, Weihui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2021
Onderwerpen:
Mechanisms of Resistance
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849007/
https://ncbi.nlm.nih.gov/pubmed/33257447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01846-20
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